Autism Spectrum: Neuropathology

0
10K


Listed below are some characteristic findings in ASD brains on molecular and cellular levels regardless of the specific genetic variation or mutation contributing to autism in a particular individual:

Limbic system with smaller neurons that are more densely packed together. Given that the limbic system is the main center of emotions and memory in the human brain, this observation may explain social impairment in ASD.
Fewer and smaller Purkinje neurons in the cerebellum. New research suggest a role of the cerebellum in emotional processing and language.
Increased number of astrocytes and microglia in the cerebral cortex. These cells provide metabolic and functional support to neurons and act as immune cells in the nervous system, respectively.
Increased brain size in early childhood causing macrocephaly in 15–20% of ASD individuals. The brain size however normalizes by mid-childhood. This variation in brain size in not uniform in the ASD brain with some parts like the frontal and temporal lobes being larger, some like the parietal and occipital lobes being normal sized, and some like cerebellar vermis, corpus callosum, and basal ganglia being smaller than neurotypical individuals.
Cell adhesion molecules that are essential to formation and maintenance of connections between neurons, neuroligins found on postsynaptic neurons that bind presynaptic cell adhesion molecules, and proteins that anchor cell adhesion molecules to neurons are all found to be mutated in ASD.

Cerca
Categorie
Leggi tutto
Weddings
The Ultimate Guide to Shopping for Your Dream Wedding: Making Every Moment Memorable
Shopping for your wedding can be both exhilarating and overwhelming. From finding the perfect...
By Dacey Rankins 2024-06-05 17:49:35 0 18K
Business
The Falcon Heavy
The Falcon Heavy is an American super-heavy launch vehicle (LV) with the ability to reuse the...
By Leonard Pokrovski 2024-07-27 12:01:38 0 21K
Business
What Equipment and Tools Are Essential for New Content Creators?
In the world of content creation, having the right equipment and tools is essential for producing...
By Dacey Rankins 2025-02-18 15:08:32 0 10K
Социальные проблемы
Опасный элемент. Radioactive. (2020)
Одержимые страстью к исследованиям, они навсегда изменили мир. Эта история о том, как великие...
By Nikolai Pokryshkin 2022-10-21 17:46:32 0 29K
Internet
How to use neural networks to write a script for TikTok, Reels and Shorts
In 2023, neural networks continue to be one of the most actively developing areas. In recent...
By FWhoop Xelqua 2023-06-12 20:21:19 0 33K

BigMoney.VIP Powered by Hosting Pokrov