Autism Spectrum: Neuropathology

0
8KB


Listed below are some characteristic findings in ASD brains on molecular and cellular levels regardless of the specific genetic variation or mutation contributing to autism in a particular individual:

Limbic system with smaller neurons that are more densely packed together. Given that the limbic system is the main center of emotions and memory in the human brain, this observation may explain social impairment in ASD.
Fewer and smaller Purkinje neurons in the cerebellum. New research suggest a role of the cerebellum in emotional processing and language.
Increased number of astrocytes and microglia in the cerebral cortex. These cells provide metabolic and functional support to neurons and act as immune cells in the nervous system, respectively.
Increased brain size in early childhood causing macrocephaly in 15–20% of ASD individuals. The brain size however normalizes by mid-childhood. This variation in brain size in not uniform in the ASD brain with some parts like the frontal and temporal lobes being larger, some like the parietal and occipital lobes being normal sized, and some like cerebellar vermis, corpus callosum, and basal ganglia being smaller than neurotypical individuals.
Cell adhesion molecules that are essential to formation and maintenance of connections between neurons, neuroligins found on postsynaptic neurons that bind presynaptic cell adhesion molecules, and proteins that anchor cell adhesion molecules to neurons are all found to be mutated in ASD.

Rechercher
Catégories
Lire la suite
Home Automation
Home Automation: Revolutionizing the Way We Live
In recent years, the concept of home automation has moved from a futuristic dream to a...
Par Dacey Rankins 2024-11-08 17:09:38 0 10KB
Искусство, культура и развлечения
Мое сердце разрывается. My Heart Goes Boom!. (2020)
Мюзикл, основанный на хитах популярной итальянской певицы Рафаэллы Карра. Мария с детства мечтала...
Par Nikolai Pokryshkin 2022-09-27 17:23:39 0 25KB
Writers Resources
Top 9 Useful Writing sites
Your creative process as a science fiction writer may be different from that of your peers, but...
Par FWhoop Xelqua 2023-07-14 18:00:30 0 20KB
Desktop Publishing
The Evolution of Desktop Publishing: Revolutionizing Design and Print Media
Desktop publishing (DTP) has transformed the way we design and produce printed materials, making...
Par Dacey Rankins 2024-11-05 15:45:29 0 9KB
Flowers
Blooming Beauties: The Joys of Shopping for Flowers
Blooming Beauties: The Joys of Shopping for Flowers In the tapestry of nature's wonders, few...
Par Leonard Pokrovski 2024-05-28 23:03:19 0 20KB

BigMoney.VIP Powered by Hosting Pokrov